Basic information of NRG1 :
| Official Symbol of Gene | NRG1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3084 |
| Official Full Name | neuregulin 1 |
| Also known as | GGF; HGL; HRG; NDF; ARIA; GGF2; HRG1; HRGA; SMDF; MST131; MSTP131; NRG1-IT2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000157168 MIM:142445; AllianceGenome:HGNC:7997 |
| Map Location | 8p12 |
| Variation Type | SNP |
| refSNP ID | rs77493513 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Isfahan, Iran |
| Sample Size | 182MS/198Health |
Literature information of multiple sclerosis :
| Pubmed ID | 35106689 |
| Year | 2022 |
| Title | Significant Association of rs77493513 Polymorphism in 3'-UTR of the NRG1 Gene with the Risk of Multiple Sclerosis Disease |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | The results show that allele C of rs77493513 polymorphism in the NRG1 gene can be a risk factor for MS |
| Mechanism/Pathway | Neuregulin 1 (NRG1) is a signaling protein that plays an important role in a variety of biological processes, including potentiate oligodendrocyte differentiation and myelination in the CNS, immune response regulation, and inflammation. |
