Basic information of HLA-DQB1 :
| Official Symbol of Gene | HLA-DQB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3119 |
| Official Full Name | major histocompatibility complex, class II, DQ beta 1 |
| Also known as | IDDM1; CELIAC1; HLA-DQB |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179344 MIM:604305; AllianceGenome:HGNC:4944 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Japanese |
| Sample Size | 24MS/23Health |
Literature information of multiple sclerosis :
| Pubmed ID | 1926126 |
| Year | 1991 |
| Title | HLA-DRB1, -DQA1, -DQBl, =-DPA1 and -DPBl genes in Japanese multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Japanese MS patients and controls were examined for the distribution of HLA-DRBl, -DQAl, - DQBl, -DPAl and -DPB1 alleles using in vitro amplification of genomic DNA and probing with sequence-specific oligonucleotides. No significant difference in frequency of the examined alleles was observed among the two groups. |
| Mechanism/Pathway | Recently, we reported that among Norwegian MS patients the disease may be more closely associated to certain combi- nations of DQAl and DQBl alleles (i.e. DQA1*0102, *0103, *0401 or *0501 in combi- nation with DQB1*0602, *0603, *0604, *0302 or *0303). In fact, 96% of Norwegian MS patients (compared to 60% of the controls) carry a combi- nation of these DQAl and DQBl alleles either in cis or in trans position, i.e. they may have DQaP heterodimers with similar peptide binding prop- erties (3). |
