Basic information of IL1B :
| Official Symbol of Gene | IL1B |
| Species | Homo sapiens |
| Entrez Gene ID | 3553 |
| Official Full Name | interleukin 1 beta |
| Also known as | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 |
| Map Location | 2q14.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Iranian population |
| Sample Size | 306MS/312Health |
Literature information of multiple sclerosis :
| Pubmed ID | 26531703 |
| Year | 2015 |
| Title | Association of interleukin-1 gene cluster polymorphisms and haplotypes with multiple sclerosis in an Iranian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A significant association was found for the IL-1β +3953 T allele [OR = 1.43, 95% CI (1.14–1.79), P value = 0.002, Pc = 0.01] and for IL-1β + 3953 T/T genotype and MS risk [OR = 1.92, 95% CI (1.25–2.96), P value = 0.005, Pc = 0.01]. Interestingly,the genotypes of the polymorphisms remained significant under recessive, co-recessive and dominant models. |
| Mechanism/Pathway | The IL-1 gene family (IL-1α, IL-1β and IL-1RA) located in a cluster on the long arm of human chromosome 2 (2q13–14), have several recognized polymorphisms |
