Basic information of IL2 :
| Official Symbol of Gene | IL2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3558 |
| Official Full Name | interleukin 2 |
| Also known as | IL-2; TCGF; lymphokine |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109471 MIM:147680; AllianceGenome:HGNC:6001 |
| Map Location | 4q27 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Iranian patients |
| Sample Size | 590MS/450Health |
Literature information of multiple sclerosis :
| Pubmed ID | 24919928 |
| Year | 2014 |
| Title | The association of ?330 interleukin-2 gene polymorphism and HLA-DR15 allele in Iranian patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our data demonstrated ?330 T IL2 allele provided major susceptibility to MS and HLA-DRB1* 1501 allele had an additive effect. In addi-tion, it seems that studies with larger sample size are required to bring about more authentic results. Our findings suggest that IL2 gene polymorphisms influence the susceptibility to MS in Iranian patients. |
| Mechanism/Pathway | The purpose of this case–control study was to evaluate the frequencies and potential genetic susceptibility of the ?330 IL2 T and G alleles and HLA-DRB1*1501 allele in Iranian patients with multiple sclerosis (MS) compared to healthy controls. |
