Basic information of TNFSF13B :
| Official Symbol of Gene | TNFSF13B |
| Species | Homo sapiens |
| Entrez Gene ID | 10673 |
| Official Full Name | TNF superfamily member 13b |
| Also known as | DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNLG7A; TNFSF20 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000102524 MIM:603969; AllianceGenome:HGNC:11929 |
| Map Location | 13q33.3 |
| Variation Type | SNP |
| refSNP ID | rs7318477 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | chip-based genotyping and next-generation sequencing |
| Disease | MS |
| Disease subtype | RRMS/PPMS |
| Population | the south Asian population |
| Sample Size | 270 cases and 555 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 26754803 |
| Year | 2015 |
| Title | European multiple sclerosis risk variants in the south Asian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We found that two-thirds of the tested variants (72/109) showed over representation of the Euro-pean risk allele in south Asian cases (p < 0.0003). In the rest of the Immunochip array, the most associated variant was rs7318477 which maps close to TNFSF13B, the gene for the B-cell-related protein BAFF. |
| Mechanism/Pathway | In less than a decade, genomewide association studies have identified over 100 single-nucleotide variants that are associated with increased risk of developing multiple sclerosis. However, since these studies have focused almost exclusively on European populations, it is unclear what role these variants might play in determining risk in other ethnic groups. |
