Basic information of CCR5 :
| Official Symbol of Gene | CCR5 |
| Species | Homo sapiens |
| Entrez Gene ID | 1234 |
| Official Full Name | C-C motif chemokine receptor 5 |
| Also known as | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606 |
| Map Location | 3p21.31 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | NA |
| Sample Size | 299 cases and 147controls |
Literature information of multiple sclerosis :
| Pubmed ID | 10803840 |
| Year | 1999 |
| Title | CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | However, age of onset was approximately 3 years later in patients carry-ing the CCR5D32 deletion (Pp0.018 after controlling for gender effects). |
| Mechanism/Pathway | An un-derlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an unde-fined environmental exposure. Full-genome screenings in multiplex MS families have identified several suscep-tibility regions, supporting a polygenic model for MS. |
