Basic information of HLA-G :
| Official Symbol of Gene | HLA-G |
| Species | Homo sapiens |
| Entrez Gene ID | 3135 |
| Official Full Name | major histocompatibility complex, class I, G |
| Also known as | MHC-G |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000204632 MIM:142871; AllianceGenome:HGNC:4964 |
| Map Location | 6p22.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Tunisian population |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 27771469 |
| Year | 2016 |
| Title | The association between functional HLA-G 14 bp insertion/deletion and +3142 C > G polymorphisms and susceptibility to multiple sclerosis. |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | ur findings showed that the +3142 C>G, but not the 14 bp INS/DEL, polymorphism may constitute a genetic susceptibility factor to MS in the Tunisian population. |
| Mechanism/Pathway | We aimed to investigate two main polymorphisms in the 3’ untranslated region (3’UTR) of the HLA-G gene [14 bp insertion/deletion (INS/DEL) and +3142 C>G] and to assess their impact on the soluble HLA-G (sHLA-G) production in patients with multiple sclerosis (MS). |
