Basic information of ICAM1 :
| Official Symbol of Gene | ICAM1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3383 |
| Official Full Name | intercellular adhesion molecule 1 |
| Also known as | BB2; CD54; P3.58 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000090339 MIM:147840; AllianceGenome:HGNC:5344 |
| Map Location | 19p13.2 |
| Variation Type | SNP |
| refSNP ID | rs5498 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Slovak population |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 28130760 |
| Year | 2016 |
| Title | Analysis of ICAM1 gene polymorphism in Slovak multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | however, patients with earlier onset of MS showed slightly higher frequencies of the homozygous G allele at rs5498 in comparison to other genotypes (P = 0 . 0 4 ) ,suggesting that GG carriers tend to induce MS at an earlier age. |
| Mechanism/Pathway | Infiltration of immune cells into CNS is one of the essential events in multiple sclerosis (MS) development.Adhesion molecules like the intercellular adhesion molecule 1 (ICAM-1) play critical role in this process. |
