Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | SNP |
| refSNP ID | rs3135388 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Slovak population |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 28130760 |
| Year | 2016 |
| Title | Analysis of ICAM1 gene polymorphism in Slovak multiple sclerosis patients |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Presence of the rs3135388 polymorphism tagging the major MS risk allele HLA-DRB1*15:01 allele was determined as well. |
| Mechanism/Pathway | Infiltration of immune cells into CNS is one of the essential events in multiple sclerosis (MS) development.Adhesion molecules like the intercellular adhesion molecule 1 (ICAM-1) play critical role in this process. |
