Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | Northern European populations |
| Sample Size | 71MS/ |
Literature information of multiple sclerosis :
| Pubmed ID | 1683865 |
| Year | 1991 |
| Title | Multiple Sclerosis and HLA: Is the Susceptibility Gene Really HLA-DR or -DQ? |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Our evidence is c~'Lsistenc w/th the hypethesir,that one of the true disease susceptibility genes for MS lies elsewhere within the HLA region and in Northern European populations is found in significant association with Dgwl5 ~nd DQw6. |
| Mechanism/Pathway | Seventy-one patients with multiple sclerosis (MS) were classified into four subgroups accord- ing to the clinical pattern of their disease; their HLA-DR and DQ polymorphisms were defined by serological methods and analysis ofTaq I digestion frggmants hybrid- izing with DRB, DQA, and DQB eDNA probes. |
