Basic information of HLA-A :
| Official Symbol of Gene | HLA-A |
| Species | Homo sapiens |
| Entrez Gene ID | 3105 |
| Official Full Name | major histocompatibility complex, class I, A |
| Also known as | HLAA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000206503 MIM:142800; AllianceGenome:HGNC:4931 |
| Map Location | 6p22.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | NA |
| Population | Tasmanians |
| Sample Size | 356MS |
Literature information of multiple sclerosis :
| Pubmed ID | 17971048 |
| Year | 2007 |
| Title | SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We identified significant effects on MS susceptibility of HLA-A*2 (OR: 0.51; P = 0.05) and A*3 (OR: 2.85; P = 0.005), and two coding polymorphisms in the MOG gene (V145I: P = 0.01, OR: 2.2; V142L: P = 0.04,OR: 0.45) after full conditioning on HLA-DRB1. |
| Mechanism/Pathway | This study is an extension to previously published work that has linked variation in the human leukocyte antigen (HLA) class I region with susceptibility to multiple sclerosis (MS) in Australians from the Island State of Tasmania. |
