Basic information of TRB :
| Official Symbol of Gene | TRB |
| Species | Homo sapiens |
| Entrez Gene ID | 6957 |
| Official Full Name | T cell receptor beta locus |
| Also known as | TCRB; TRB@ |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:HGNC:12155 |
| Map Location | 7q34 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | NA |
| Sample Size | 40MS/20Health |
Literature information of multiple sclerosis :
| Pubmed ID | 9626994 |
| Year | 1998 |
| Title | Detection of skewed T-cell receptor V-b gene usage in the peripheral blood of patients with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | These data indicate that certain MS patients have abnormal TCRBV gene expression. Such abnormalities are caused by polyclonal expansions of T lymphocyte subpopulations that use the same TCRBV gene families, are unstable and preferentially observed early in the course of the disease |
| Mechanism/Pathway | Such abnormalities are caused by polyclonal expansions of T lymphocyte subpopulations that use the same TCRBV gene families, are unstable and preferentially observed early in the course of the disease |
