Basic information of CCR2 :
| Official Symbol of Gene | CCR2 |
| Species | Homo sapiens |
| Entrez Gene ID | 729230 |
| Official Full Name | C-C motif chemokine receptor 2 |
| Also known as | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121807 MIM:601267; AllianceGenome:HGNC:1603 |
| Map Location | 3p21.31 |
| Variation Type | SNP |
| refSNP ID | rs1799864 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | Slovak origin |
| Sample Size | 301MS/342Health |
Literature information of multiple sclerosis :
| Pubmed ID | 25604634 |
| Year | 2015 |
| Title | The +190 G/A (rs1799864) polymorphism in the C–C c h e m o k i n e receptor 2 (CCR2) gene is associated with susceptibility to multiple sclerosis in HLA-DRB1*15:01-negative individuals |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | In conclusion,our results suggest that CCR2 +190 G/A polymorphism may increase the susceptibility to MS, but its action seems to be restricted to individuals who do not possess the major risk allele HLA-DRB1*15:01. |
| Mechanism/Pathway | C–C chemokine receptor 2 (CCR2) is one of the key players involved in the transmigration of mononuclear cells into the central nervous system (CNS) and subsequent development of multiple sclerosis (MS). |
