Basic information of HSPA4 :
| Official Symbol of Gene | HSPA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 3308 |
| Official Full Name | heat shock protein family A (Hsp70) member 4 |
| Also known as | RY; APG-2; HSPH2; hsp70; hsp70RY; HEL-S-5a; HS24/P52 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000170606 MIM:601113; AllianceGenome:HGNC:5237 |
| Map Location | 5q31.1 |
| Variation Type | SNP |
| refSNP ID | rs2227956 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 191MS/365Health |
Literature information of multiple sclerosis :
| Pubmed ID | 27609295 |
| Year | 2016 |
| Title | Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | We reported a strong association between rs2227956 polymorphism and MS risk, which is independent from the association with HSP70-2 rs1061581, and a significant link between hsp70-hom protein expression and MS severity. |
| Mechanism/Pathway | Immune-mediated and neurodegenerative mechanisms are involved in multiple sclerosis (MS). Growing evi-dences highlight the role of HSP70 genes in the susceptibility of some neurological diseases. |
