Basic information of HLA-DQA1 :
| Official Symbol of Gene | HLA-DQA1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3117 |
| Official Full Name | major histocompatibility complex, class II, DQ alpha 1 |
| Also known as | DQA1; DQ-A1; CELIAC1; HLA-DQA; HLA-DQB1; HLA-DQA1* |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196735 MIM:146880; AllianceGenome:HGNC:4942 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | Sardinian population |
| Sample Size | 288MS |
Literature information of multiple sclerosis :
| Pubmed ID | 9668164 |
| Year | 1998 |
| Title | DRB1–DQA1–DQB1 loci and multiple sclerosis predisposition in the Sardinian population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Cross-ethnic comparison between the two HLA haplotypes associated with MS in Sardi-nians and the DRB1*1501 (DR2)–DQA1*0102–DQB1*0602 haplotype, associated with MS in other Caucasian populations, failed to identify any shared epitopes in the DR and DQ molecules that segregated with disease sus-ceptibility. |
| Mechanism/Pathway | Previous genetic analyses have suggested that the MHC/HLA region on chromosome 6p21 contains an MS-predisposing component. |
