Basic information of NOS2A :
| Official Symbol of Gene | NOS2A |
| Species | Homo sapiens |
| Entrez Gene ID | 4843 |
| Official Full Name | nitric oxide synthase 2 |
| Also known as | NOS; INOS; NOS2A; HEP-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000007171 MIM:163730; AllianceGenome:HGNC:7873 |
| Map Location | 17q11.2 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | European descent |
| Sample Size | 2159MS/4106Health |
Literature information of multiple sclerosis :
| Pubmed ID | 18580885 |
| Year | 2008 |
| Title | Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The very largest study of NOS2A variation in MS, to date, excludes even a modest role for this locus in susceptibility. |
| Mechanism/Pathway | Variation in the major histocompatibility complex (MHC) on chromosome 6p21, specifically the HLA-DRB1*15 haplotype, is the strongest genetic factor for MS, yet it is estimated to account for only a portion of risk for the disease. |
