Basic information of OAS1 :
| Official Symbol of Gene | OAS1 |
| Species | Homo sapiens |
| Entrez Gene ID | 4938 |
| Official Full Name | 2'-5'-oligoadenylate synthetase 1 |
| Also known as | OIAS; IFI-4; OIASI; IMD100; E18/E16 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089127 MIM:164350; AllianceGenome:HGNC:8086 |
| Map Location | 12q24.13 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 401MS/394Health |
Literature information of multiple sclerosis :
| Pubmed ID | 20679634 |
| Year | 2010 |
| Title | OAS1: a multiple sclerosis susceptibility gene that influences disease severity |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | A functional OAS1 SNP, AA genotype, confers susceptibility to MS and the GG genotype may protect against increased disease activity. |
| Mechanism/Pathway | A single nucleotide polymorphism (SNP) in exon 7 of OAS1 results in differential RNAseL enzyme activity, the A allele coding for a truncated form with low activity and the G conferring high activity. |
