Basic information of HLA-A :
| Official Symbol of Gene | HLA-A |
| Species | Homo sapiens |
| Entrez Gene ID | 3105 |
| Official Full Name | major histocompatibility complex, class I, A |
| Also known as | HLAA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000206503 MIM:142800; AllianceGenome:HGNC:4931 |
| Map Location | 6p22.1 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 843MS/1209Health |
Literature information of multiple sclerosis :
| Pubmed ID | 21303861 |
| Year | 2011 |
| Title | Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | Among those with both genetic risk factors, smoking increased the risk by a factor of 2.8 in comparison with a factor of 1.4 among those without the genetic risk factors. |
| Mechanism/Pathway | Both genetic and environmental factors display low or modest associations with multiple sclerosis. Hypothetically, gene–envir-onment interactions may exert much stronger effects. In this study, we investigated potential interactions between genetic risk factors and smoking in relation to risk of developing multiple sclerosis. |
