Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | Allele |
| refSNP ID | NA |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | Canadian and of European descent. |
| Sample Size | 1970MS |
Literature information of multiple sclerosis :
| Pubmed ID | 18765817 |
| Year | 2008 |
| Title | HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Positive |
| Result | These findings strongly imply that differences among HLA-DRB1*15 haplotypes will furnish the basis differences among HLA-DRB1*15 haplotypes will furnish the basis that the MHC haplotype is the fundamental unit of genetic control of immune response. |
| Mechanism/Pathway | HLA-DRB1 alleles, constituting the strongest MS suscepti-bility factors, have been widely exploited in research including construction of transgenic animal models of MS. |
