Basic information of FCRL3 :
| Official Symbol of Gene | FCRL3 |
| Species | Homo sapiens |
| Entrez Gene ID | 115352 |
| Official Full Name | Fc receptor like 3 |
| Also known as | MAIA; FCRH3; IFGP3; IRTA3; SPAP2; CD307c |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000160856 MIM:606510; AllianceGenome:HGNC:18506 |
| Map Location | 1q23.1 |
| Variation Type | SNP |
| refSNP ID | rs11264799 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | the South of Spain. |
| Sample Size | 645MS/786Health |
Literature information of multiple sclerosis :
| Pubmed ID | 18313765 |
| Year | 2008 |
| Title | The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95% C.I. = 0.70–0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. |
| Mechanism/Pathway | Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, |
