Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs11567686 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | Turkish population |
| Sample Size | 364 patients/191 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30443838 |
| Year | 2019 |
| Title | Association Between IL7R Promoter Polymorphisms and Multiple Sclerosis in Turkish Population |
Results of multiple sclerosis :
| Risk Type | Phenotypic risk |
| Main Result | Positive |
| Result | In conclusion, this is the first study to show a significant association between the IL7R promoter polymorphisms and the age of onset of MS |
| Mechanism/Pathway | On the cell surface,cytokine form a complex where they induce the maturation of IL7R and IL7 B and T cells, and play a crucial role on the peripherical T cell hemostasis and immune tolerance |
