Basic information of TLR3 :
| Official Symbol of Gene | TLR3 |
| Species | Homo sapiens |
| Entrez Gene ID | 7098 |
| Official Full Name | toll like receptor 3 |
| Also known as | CD283; IIAE2; IMD83 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000164342 MIM:603029; AllianceGenome:HGNC:11849 |
| Map Location | 4q35.1 |
| Variation Type | SNP |
| refSNP ID | rs3775291 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | capillary gel electrophoresis and TaqMan genotyping assay techniques |
| Disease | MS |
| Disease subtype | N/A |
| Population | Australian |
| Sample Size | 205 MS patients and 196 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20483009 |
| Year | 2010 |
| Title | Investigation of the [-/A]8 and C1236T genetic variations within the human Toll-like receptor 3 gene for association with multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | N/A |
| Main Result | negative |
| Result | Although the role of TLR3 and the wider toll-like receptor family remain significant in neurological and CNS inflammatory disorders, our current work does not support a role for the two tested variants in this gene with regard to MS susceptibility. |
| Mechanism/Pathway | TLRs are thought to participate in modulating the Th2 (anti-inflammatory) to Th1(inflammatory) shift. |
