Basic information of MANBA :
| Official Symbol of Gene | MANBA |
| Species | Homo sapiens |
| Entrez Gene ID | 4126 |
| Official Full Name | mannosidase beta |
| Also known as | MANB1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109323 MIM:609489; AllianceGenome:HGNC:6831 |
| Map Location | 4q24 |
| Variation Type | SNP |
| refSNP ID | rs7665090 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 152 MS patients,112 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35897697 |
| Year | 2022 |
| Title | Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Our work provides new evidence highlighting the impact of the MS-risk variant, rs7665090, and the role of MANBA in the immunopathology of MS. |
| Mechanism/Pathway | Significantly decreased enzymatic activity and lysosomal function and significantly lower lymphocyte and metabolic activations in response to stimulus were detected in MS carriers of the GG genotype compared to controls with the same genotype, while the rs7665090*AA genotype led to similar effects both in patients and controls. |
