Basic information of GRIN1 :
| Official Symbol of Gene | GRIN1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2902 |
| Official Full Name | glutamate ionotropic receptor NMDA type subunit 1 |
| Also known as | NR1; MRD8; GluN1; NMDA1; DEE101; NDHMSD; NDHMSR; NMD-R1; NMDAR1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000176884 MIM:138249; AllianceGenome:HGNC:4584 |
| Map Location | 9q34.3 |
| Variation Type | SNP |
| refSNP ID | rs4880213 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS,PPMS |
| Population | European |
| Sample Size | 2239 subjects of European |
Literature information of multiple sclerosis :
| Pubmed ID | 23840674 |
| Year | 2013 |
| Title | Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The C allele of rs4880213 was found to be associated with reduced NMDAR-mediated cortical excitability, and with increased probability of having more disability than the CT/TT MS subjects. |
| Mechanism/Pathway | Signaling through glutamate NMDARs enhances both compensatory synaptic plasticity and excitotoxic neurodegeneration, impacting in opposite ways on RR-MS and PP-MS pathophysiological mechanisms. |
