Basic information of CASP8 :
| Official Symbol of Gene | CASP8 |
| Species | Homo sapiens |
| Entrez Gene ID | 841 |
| Official Full Name | caspase 8 |
| Also known as | CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000064012 MIM:601763; AllianceGenome:HGNC:1509 |
| Map Location | 2q33.1 |
| Variation Type | SNP |
| refSNP ID | rs12990906 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | PPMS |
| Population | N/A |
| Sample Size | 546 MS patients and 547 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20363033 |
| Year | 2010 |
| Title | Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | For SNP rs12990906, CT heterozygosity was associated with PPMS when compared with controls (OR= 1.9; corrected p-value= 0.030). |
| Mechanism/Pathway | N/A |
