Basic information of IL12B :
| Official Symbol of Gene | IL12B |
| Species | Homo sapiens |
| Entrez Gene ID | 3593 |
| Official Full Name | interleukin 12B |
| Also known as | CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000113302 MIM:161561; AllianceGenome:HGNC:5970 |
| Map Location | 5q33.3 |
| Variation Type | SNP |
| refSNP ID | rs3212227 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Bulgarian |
| Sample Size | 144 cases and 120 age–sex–BMI-matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30554348 |
| Year | 2019 |
| Title | IL12B gene polymorphisms have sex-specific effects in relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Our results suggest that sex-specific effects of IL12B polymorphisms, rs17860508 and rs3212227, on genetic predisposition and disease course of RRMS, is probably mediated by their gender-dependent functional effect on IL-12p40-containing cytokines. |
| Mechanism/Pathway | Our results suggest that sex-specific effects of IL12B polymorphisms, rs17860508 and rs3212227, on genetic predisposition and disease course of RRMS, is probably mediated by their gender-dependent functional effect on IL-12p40-containing cytokines. |
