Basic information of CIITA :
| Official Symbol of Gene | CIITA |
| Species | Homo sapiens |
| Entrez Gene ID | 4261 |
| Official Full Name | class II major histocompatibility complex transactivator |
| Also known as | C2TA; NLRA; MHC2TA; CIITAIV |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067 |
| Map Location | 16p13.13 |
| Variation Type | SNP |
| refSNP ID | rs4774 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | N/A |
| Population | European ancestry |
| Sample Size | 1320 cases and 1363 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20211854 |
| Year | 2010 |
| Title | CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Rs4774 (missense +1614G/C; G500A) was associated with MS (P = 4.9 x 10(-3)), particularly in DRB1*1501 +individuals (P = 1 x 10(-4)). |
| Mechanism/Pathway | N/A |
