Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
| Variation Type | DRB1*15:01 allele |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | Illumina exome chip |
| Disease | MS |
| Disease subtype | N/A |
| Population | Swedish |
| Sample Size | 6985 cases, 6569 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33687974 |
| Year | 2021 |
| Title | DRB1-environment interactions in multiple sclerosis etiology: results from two Swedish case-control studies |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The effect of each DRB1*15:01 allele on MS risk was additive on the log-odds scale for each additional allele. Interaction between DRB1*15:01 and each assessed environmental factor was of similar magnitude regardless of the number of DRB1*15:01 alleles, although ORs were affected. When any of the environmental factors were present in DRB1*15:01 carriers without the protective A*02:01 allele, a three-way interaction occurred and rendered high ORs, especially among DRB1*15:01 homozygotes (OR 20.0, 95% CI 13.1 to 30.5 among smokers, OR 21.9, 95% CI 15.0 to 31.8 among those with elevated EBNA-1 antibody levels, and OR 44.3, 95% CI 13.5 to 145 among those who reported adolescent overweight/obesity). |
| Mechanism/Pathway | HLA molecules are also involved in regulating thymic selection of the mature T-cell repertoire. By central tolerance mechanisms, potentially autoaggressive T cells with a propensity to recognise CNS autoantigens may to a higher degree survive in DRB1*15:01 positive subjects. |
