Basic information of PLCG2 :
| Official Symbol of Gene | PLCG2 |
| Species | Homo sapiens |
| Entrez Gene ID | 5336 |
| Official Full Name | phospholipase C gamma 2 |
| Also known as | FCAS3; APLAID; PLC-IV; PLC-gamma-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197943 MIM:600220; AllianceGenome:HGNC:9066 |
| Map Location | 16q23.3 |
| Variation Type | SNP |
| refSNP ID | rs72824905 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | GWAS |
| Disease | MS |
| Disease subtype | N/A |
| Population | Australia,10 European countries,and multiple US states |
| Sample Size | 32,367 MS cases and 36,012 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33523007 |
| Year | 2021 |
| Title | PLCG2 rs72824905 Variant Reduces the Risk of Alzheimer's Disease and Multiple Sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Importantly, rs72824905 G allele could also significantly reduce the risk of MS with OR = 0.94, p = 3.63E-05. Hence, the effects of rs72824905 on AD and MS are consistent. |
| Mechanism/Pathway | N/A |
