Basic information of CD33 :

Official Symbol of Gene	CD33
Species	Homo sapiens
Entrez Gene ID	945
Official Full Name	CD33 molecule
Also known as	p67; SIGLEC3; SIGLEC-3
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000105383 MIM:159590; AllianceGenome:HGNC:1659
Map Location	19q13.41
Variation Type	SNP
refSNP ID	rs3865444

Sample information of multiple sclerosis:

Detected Sample	Blood
Sample Detail	N/A
Detected Method	TaqMan
Disease	MS
Disease subtype	N/A
Population	Greece
Sample Size	1396 MS cases and 400 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	33198164
Year	2020
Title	Multiple Sclerosis: Shall We Target CD33?

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	positive
Result	Therefore, we could assume that the CD33 rs3865444 GG genotype predisposes towards MS by increasing CD33 cell surface expression and decreasing the alternatively spliced CD33m variant, thus altering myeloid cells function.
Mechanism/Pathway	Therefore, we could assume that the CD33 rs3865444 GG genotype predisposes towards MS by increasing CD33 cell surface expression and decreasing the alternatively spliced CD33m variant, thus altering myeloid cells function.