Basic information of CD58 :
| Official Symbol of Gene | CD58 |
| Species | Homo sapiens |
| Entrez Gene ID | 965 |
| Official Full Name | CD58 molecule |
| Also known as | ag3; LFA3; LFA-3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000116815 MIM:153420; AllianceGenome:HGNC:1688 |
| Map Location | 1p13.1 |
| Variation Type | SNP |
| refSNP ID | rs1414273 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | eQTL analysis |
| Disease | MS |
| Disease subtype | N/A |
| Population | north-east Germany |
| Sample Size | 32 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 30730892 |
| Year | 2019 |
| Title | A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | To conclude, our analysis suggests that SNP rs1414273 is possibly implicated in the development of MS. |
| Mechanism/Pathway | We provide evidence that the SNP rs1414273 might alter Drosha cleavage activity, thereby provoking partial uncoupling of CD58 gene expression and microRNA-548ac production from the shared primary transcript in immune cells. |
