Basic information of CCR5 :
| Official Symbol of Gene | CCR5 |
| Species | Homo sapiens |
| Entrez Gene ID | 1234 |
| Official Full Name | C-C motif chemokine receptor 5 |
| Also known as | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000160791 MIM:601373; AllianceGenome:HGNC:1606 |
| Map Location | 3p21.31 |
| Variation Type | A 32-bp deletion in the CCR5 |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | peripheral blood cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Israel |
| Sample Size | 138 MS |
Literature information of multiple sclerosis :
| Pubmed ID | 12874407 |
| Year | 2003 |
| Title | A mutated CCR5 gene may have favorable prognostic implications in MS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Progression to disability was prolonged in Delta32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS. |
| Mechanism/Pathway | The current findings, taken together with increased expression of CCR5 on circulating T cells in MS patients compared with healthy control subjects,the aberrant migration of MS-derived T cells toward RANTES and MIP-1 due to overexpression of their CCR5 receptors,and the increase in CCR5+ circulating CD4+cells during acute MS relapses,suggest that CCR5 antagonists could be considered a potential target for therapeutic intervention in MS. |
