Basic information of SH2D2A :
| Official Symbol of Gene | SH2D2A |
| Species | Homo sapiens |
| Entrez Gene ID | 9047 |
| Official Full Name | SH2 domain containing 2A |
| Also known as | SCAP; TSAD; VRAP; F2771 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000027869 MIM:604514; AllianceGenome:HGNC:10821 |
| Map Location | 1q23.1 |
| Variation Type | SH2D2A GA repeat |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Oslo |
| Sample Size | 313 Norwegian unrelated MS patients and the 277 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 11528519 |
| Year | 2001 |
| Title | The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | N/A |
| Main Result | negative |
| Result | No linkage or association of MS to four genetic markers flanking the SH2D2A gene was observed. |
| Mechanism/Pathway | Since the SH2D2A protein modulates T cell activation, this may be a mechanism for how short SH2D2A alleles confer susceptibility to develop MS. |
