Basic information of HLA-DRB1 :

Official Symbol of Gene	HLA-DRB1
Species	Homo sapiens
Entrez Gene ID	3123
Official Full Name	major histocompatibility complex, class II, DR beta 1
Also known as	SS1; DRB1; HLA-DRB; HLA-DR1B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948
Map Location	6p21.32
Variation Type	HLA-DR15
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	Blood
Sample Detail	N/A
Detected Method	TaqI-digested, Southern-blot
Disease	MS
Disease subtype	N/A
Population	Swedish
Sample Size	Nine hundred forty-eight patients,455 control subjects

Literature information of multiple sclerosis :

Pubmed ID	10939572
Year	2000
Title	HLA-DR15 is associated with lower age at onset in multiple sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	positive
Result	We found that, in addition to DR15, DR17 is positively associated with susceptibility to MS; that none of the HLA-DRB1 alleles influences course or outcome in MS; that carriers of DR15 are prone to MS development at an earlier age than noncarriers; and that differences in DR15 positivity rates, after stratification for diagnostic category and examination results, seem to reflect a gradient of phenocopy contamination, with rates increasing in proportion to the degree of clinical or paraclinical verification of the MS diagnosis.
Mechanism/Pathway	N/A