Basic information of SIRPG :
| Official Symbol of Gene | SIRPG |
| Species | Homo sapiens |
| Entrez Gene ID | 55423 |
| Official Full Name | signal regulatory protein gamma |
| Also known as | CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089012 MIM:605466; AllianceGenome:HGNC:15757 |
| Map Location | 20p13 |
| Variation Type | SNP |
| refSNP ID | rs2281808 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | TaqMan |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size |
33 treatment na |
Literature information of multiple sclerosis :
| Pubmed ID | 32853219 |
| Year | 2020 |
| Title | Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | As compared to HD, RRMS and T1D patients show significantly greater preponderance of rs2281808 CT/TT carriers. |
| Mechanism/Pathway | Interestingly, increased frequencies of SIRPγlow T-cells in RRMS and T1D positively correlated with proinflammatory molecules from T-cells. |
