Basic information of WT1 :
| Official Symbol of Gene | WT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 7490 |
| Official Full Name | WT1 transcription factor |
| Also known as | GUD; AWT1; WAGR; WT-1; WT33; NPHS4; WIT-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000184937 MIM:607102; AllianceGenome:HGNC:12796 |
| Map Location | 11p13 |
| Variation Type | SNP |
| refSNP ID | rs5030244 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | Illumina HumanOmniExpress12v1_A array,ANZgene MS GWAS |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 169 participants with MS |
Literature information of multiple sclerosis :
| Pubmed ID | 25312909 |
| Year | 2015 |
| Title | Modulating effects of WT1 on interferon-β-vitamin D association in MS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | We have demonstrated that two-independent SNPs (rs10767935 and rs5030244) in WT1 modified the IFN-β-25(OH)D association in patients with MS. |
| Mechanism/Pathway | These findings indicate that WT1 variants may play a role in altering the effects of IFN-β on vitamin D in MS. |
