Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 7132 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | R92Q |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | CIS, 1; relapsing–remitting MS, 16; secondary progressive MS, 2; primary progressive MS, 2 |
| Population | N/A |
| Sample Size | 700 MS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 19029521 |
| Year | 2008 |
| Title | Multiple sclerosis and the TNFRSF1A R92Q mutation: clinical characteristics of 21 cases |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The penetrance of the R92Q mutation in affected family members was higher than reported. We recommend careful observation of MS patients with coexisting TRAPS with regard to unexpected side effects of immunomodulatory therapies. |
| Mechanism/Pathway | N/A |
