Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | SNP |
| refSNP ID | rs2104286 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | central coastal area of China |
| Sample Size | 263 MS patients from the Han nationality and 138 MS patients from the Hui nationality, 440 healthy volunteers |
Literature information of multiple sclerosis :
| Pubmed ID | 30352019 |
| Year | 2018 |
| Title | A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Han and Hui nationalities. |
| Mechanism/Pathway | Thus,the correlation between IL2RA SNPs and MS susceptibility may be related to its involvement in immune regulation, and more researches are urgent to study the underlying mechanisms. |
