Basic information of IL2RA :
| Official Symbol of Gene | IL2RA |
| Species | Homo sapiens |
| Entrez Gene ID | 3559 |
| Official Full Name | interleukin 2 receptor subunit alpha |
| Also known as | p55; CD25; IL2R; IMD41; TCGFR; IDDM10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000134460 MIM:147730; AllianceGenome:HGNC:6008 |
| Map Location | 10p15.1 |
| Variation Type | SNP |
| refSNP ID | rs11594656 |
Sample information of multiple sclerosis:
| Detected Sample | Blood |
| Sample Detail | N/A |
| Detected Method | PCR,TaqMan |
| Disease | MS |
| Disease subtype | N/A |
| Population | Spain |
| Sample Size | 430 multiple sclerosis (MS) patients and in 550 ethnically matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20179739 |
| Year | 2010 |
| Title | Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Replication and meta-analysis with results from an independent cohort of 771 MS patients and 759 controls from AndalucÃa (Spain) confirmed the association of polymorphisms in the IL2RA gene (P(Mantel-Haenszel,) odds ratio (OR)(M-H) (95% confidence interval, CI) for rs2104286: 0.0001, 0.75 (0.65-0.87); for rs11594656/rs35285258: 0.004, 1.19 (1.06-1.34); for rs41295061: 0.03, 0.77 (0.60-0.98)) |
| Mechanism/Pathway | The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation. |
