Basic information of Ace :
| Official Symbol of Gene | Ace |
| Species | Homo sapiens |
| Entrez Gene ID | 11421 |
| Official Full Name | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 |
| Also known as | CD143 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020681 AllianceGenome:MGI:87874 |
| Map Location | 11 E1; 11 68.84 cM |
| Variation Type | SNP |
| refSNP ID | rs1799752 |
Sample information of multiple sclerosis:
| Detected Sample | N/A |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Hamadan Province, West of Iran |
| Sample Size | 391 relapsing-remitting (RR) MS patients and 380 age-and sex-matched controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30218954 |
| Year | 2018 |
| Title | Polymorphisms in the angiotensin I converting enzyme (ACE) gene are associated with multiple sclerosis risk and response to Interferon-β treatment |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | positive |
| Result | Analysis of genotype and allele frequencies of the mentioned variants in total MS patients compared with controls showed significant overrepresentation of the I allele of the rs1799752 in MS patients compared with healthy subjects (Adjusted P value=0.03, OR (95%CI)=1.28 (1.05–1.57). |
| Mechanism/Pathway | The present study provides further evidences for the role of ACE in MS risk or response of patients to IFN-β treatment. |
