Basic information of EBF1 :

Official Symbol of Gene	EBF1
Species	Homo sapiens
Entrez Gene ID	1879
Official Full Name	EBF transcription factor 1
Also known as	EBF; COE1; OLF1; O/E-1
Gene Type	N/A
dbXrefs	Ensembl:ENSG00000164330 MIM:164343; AllianceGenome:HGNC:3126
Map Location	5q33.3
Variation Type	SNP
refSNP ID	rs1368297

Sample information of multiple sclerosis:

Detected Sample	Blood
Sample Detail	N/A
Detected Method	Taq polymerase
Disease	MS
Disease subtype	N/A
Population	Spanish
Sample Size	356 MS patients and 540 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	16255771
Year	2006
Title	Early B-cell Factor gene association with multiple sclerosis in the Spanish population

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	positive
Result	Our data support EBF1 gene association with MS pathogenesis in the Spanish white population. Two genetic markers within the EBF1 gene have been found associated with this neurological disease, indicative either of their causative role or that of some other polymorphism in linkage disequilibrium with them.
Mechanism/Pathway	Our data suggest that the EBF1 gene involved in B-cell development, adipogenesis and axonal damage play a causative role in MS. Many mechanistic ties between axonal damage, tau pathology, intrathecal B1 subpopulation responsible for IgM secretion, conventional B cells, and the EBF1 gene role in MS susceptibility could be thought up. Confirmation in an independent cohort would substantiate our hypothesis about the implications of this gene in MS.