Basic information of TNFRSF1A :
| Official Symbol of Gene | TNFRSF1A |
| Species | Homo sapiens |
| Entrez Gene ID | 7132 |
| Official Full Name | TNF receptor superfamily member 1A |
| Also known as | FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000067182 MIM:191190; AllianceGenome:HGNC:11916 |
| Map Location | 12p13.31 |
| Variation Type | SNP |
| refSNP ID | rs1800693 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 541 MS patients and 724 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 30009568 |
| Year | 2017 |
| Title | TNFRSF1A polymorphisms and their role in multiple sclerosis susceptibility and severity in the Slovak population |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | our results provide support for a sex†and HLAâ€DRB1*15:01â€independent association of TNFRSF1A rs1800693 SNP with MS susceptibility, but not with age at disease onset, severity or rate of disability accumulation |
| Result | Polymerase chain reaction–restriction fragment length poly†morphism method was used to genotype both TNFRSF1A polymorphisms in 541 MS patients and 724 healthy controls. Logistic regression analysis revealed a significantly increased risk of developing MS for the carriers of rs1800693 C allele (TC + CC vs.TT: pcorr = 0.005; OR = 1.61; 95% CI = 1.23–2.12), irrespective of sex and carriage of the major MS risk allele HLAâ€DRB1*15:01. On the other hand, no association could be found between rs4149584 and MS risk (GA + AA vs. GG: pcorr = 1.00; OR = 1.25; 95% CI = 0.71–2.21) |
| Mechanism/Pathway | tumour necrosis factor recep†tor superfamily member 1A (TNFRSF1A) gene on chromosome 12p13 was identified as a MS susceptibility gene in subjects of European an†cestry |
