Basic information of NR5A1 :
| Official Symbol of Gene | NR5A1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2516 |
| Official Full Name | nuclear receptor subfamily 5 group A member 1 |
| Also known as | ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXX4; SRXY3; hSF-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136931 MIM:184757; AllianceGenome:HGNC:7983 |
| Map Location | 9q33.3 |
| Variation Type | gene polymorphisms |
| refSNP ID | N/A |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | French |
| Sample Size | To test 23 genes coding for growth factors and their receptors as candidates for MS genetic susceptibility in 84 multiplex families of French origin by linkage analysis |
Literature information of multiple sclerosis :
| Pubmed ID | 9748021 |
| Year | 1998 |
| Title | A systematic study of oligodendrocyte growth factors as candidates for genetic susceptibility to MS |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | TGFP3, the only gene highlighted by this study, deserves further analysis |
| Result | The lower limits of the relative risk (Xs) possibly excluded for any candidate gene ranged from 1.3 to 2.8. Positive MLS values (up to 0.93) were observed for transforming growth factor beta 3 (TGFP3) in HLA DR15-associated families, suggesting a possible role for this growth factor in interaction with HLA. Conclusions: Oligodendrocyte growth factors do not play a significant role in MS genetic susceptibility, at least in the tested sample |
| Mechanism/Pathway | kage of MS to human leukocyte antigen (HLA) DR15 |
