Basic information of HLA-DRB1 :

Official Symbol of Gene	HLA-DRB1
Species	Homo sapiens
Entrez Gene ID	3123
Official Full Name	major histocompatibility complex, class II, DR beta 1
Also known as	SS1; DRB1; HLA-DRB; HLA-DR1B
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948
Map Location	6p21.32
Variation Type	gene polymorphisms
refSNP ID	N/A

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	Sixty-six unrelated caucasian patients presenting at the Neurology Department with clinically definite MS [28] and relapsing remitting disease course were subtyped for HLA-DRB1 and -DQB1, and 46 patients for -DQA1

Literature information of multiple sclerosis :

Pubmed ID	11082515
Year	2000
Title	Multiple Sclerosis Associated Amino Acids of Polymorphic Regions Relevant for the HLA Antigen Binding Are Confined to HLA-DR2

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Thus, the contribution of HLA class II to the pathogenesis of MS is not mediated by allele-overlapping antigen binding sites, but is confined to the disease associated HLA allele
Result	We found a significant association with disease for the appearance of proline at position 11, arginine at position 13, and alanine at position 71 of HLA-DRb1. Surprisingly, we identified only residues preferentially expressed in the MS group that were related to HLA-DR2
Mechanism/Pathway	relapsing-remitting versus primary chronic progressive MS, are influenced by the HLA-genotype