Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs6897932 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Europeans and Americans of European origin |
| Sample Size | 3324 cases and 5032 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 18721276 |
| Year | 2008 |
| Title | The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result |
resulting in stronger association with similar OR (P |
| Result | This outcome indicates that other types of genome variants should be required for the development and progression of MS, which may vary among populations and is consistent with a complex disease model in which multiple genes and environmental factors contribute to the phenotype |
| Mechanism/Pathway | these data suggest that carriers of the ‘C’ allele at rs6897932 produce less membrane-bound IL7RA protein compared with carriers of the ‘T’ allele, leading to a further increase of the soluble form of IL7RA |
