Basic information of GPC1 :
| Official Symbol of Gene | GPC1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2817 |
| Official Full Name | glypican 1 |
| Also known as | glypican |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000063660 MIM:600395; AllianceGenome:HGNC:4449 |
| Map Location | 2q37.3 |
| Variation Type | SNP |
| refSNP ID | rs9523787 |
Sample information of multiple sclerosis:
| Detected Sample | Bone Marrow |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 1355 patients |
Literature information of multiple sclerosis :
| Pubmed ID | 20692050 |
| Year | 2010 |
| Title | Association to the Glypican-5 gene in multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (pcorr= 0.006) |
| Result | Thus, this study supports that MS susceptibility at 13q31–32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene |
| Mechanism/Pathway | MSassociated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31–32 and the Glypican-5 and Glypican-6 genes |
