Basic information of IRF5 :

Official Symbol of Gene	IRF5
Species	Homo sapiens
Entrez Gene ID	3663
Official Full Name	interferon regulatory factor
Also known as	SLEB10
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000128604 MIM:607218; AllianceGenome:HGNC:6120
Map Location	7q32.1
Variation Type	SNP
refSNP ID	rs4728142

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	588 MS samples and 567 healthy controls

Literature information of multiple sclerosis :

Pubmed ID	20861862
Year	2010
Title	Validation of IRF5 as multiple sclerosis risk gene: putative role in interferon beta therapy and human herpes virus-6 infection

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Additionally, trends for association were observed between rs3807306T and infection with HHV-6 [p 0.05, OR (95% CI) 1.56 (1.00–2.44)] and response to IFN-b therapy [P 0.09, OR (95% CI) 1.39 (0.95–2.05)].
Result	The combined analysis of available datasets yielded an effect size on MS with odds ratio (OR)MantelHaenszel 1.14 (Po0.002) for the IRF5 polymorphisms rs4728142 and rs3807306
Mechanism/Pathway	1 IRF pathways also participate in the regulation of the antiviral innate response.2 IRF5-induced innate antiviral responses appear to result in a broad alteration of the transcriptional profile of cellular genes.3,4 IRF5 is expressed mainly in lymphocytes and dendritic cells, but it is induced in other cells in response to type I interferon (IFN)5