Basic information of IL7R :
| Official Symbol of Gene | IL7R |
| Species | Homo sapiens |
| Entrez Gene ID | 3575 |
| Official Full Name | interleukin 7 receptor |
| Also known as | ILRA; CD127; IL7RA; CDW127; IMD104; sIL-7R; lnc-IL7R; IL7Ralpha; IL-7Ralpha; IL-7R-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168685 MIM:146661; AllianceGenome:HGNC:6024 |
| Map Location | 5p13.2 |
| Variation Type | SNP |
| refSNP ID | rs10058453 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | PPMS, SPMS, RRMS |
| Population | Sweden, Norway, Denmark and Finland |
| Sample Size | 1,210 individuals with multiple sclerosis and 1,234 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17660816 |
| Year | 2007 |
| Title | Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis |
Results of multiple sclerosis :
| Risk Type | Disease risk |
| Main Result | Negative |
| Result | Three of the tag SNPs showed significant association in the singlepoint analysis that survived after Bonferroni correction for multiple comparisons: rs2303137 (Puncorrected = 0.004, PBonferroni = 0.05), rs6871748 (Puncorrected = 0.003 and PBonferroni = 0.04) and the exon 6 nonsynonymous SNP rs6897932 (Puncorrected= 0.001, PBonferroni= 0.02). |
| Mechanism/Pathway | IL7R is located on chromosome 5p13, a region occasionally suggested to be linked with multiple sclerosis. |
