Basic information of MBP :

Official Symbol of Gene	MBP
Species	Homo sapiens
Entrez Gene ID	4155
Official Full Name	myelin basic protein
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000197971 MIM:159430; AllianceGenome:HGNC:6925
Map Location	18q23
Variation Type	SNP
refSNP ID	rs12959006

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	291 patients (66.7% female) were included in the study

Literature information of multiple sclerosis :

Pubmed ID	32431704
Year	2020
Title	A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	Lymphocyte activation measured by CD69 expression was also analyzed according to sex and rs12959006 genotype. The rs12959006 polymorphism contributed significantly to a higher number of relapses at 5 years after onset only in male patients (rs12959006TT β = 0.74 [0.36–1.09]; p = 7 × 105 ). Titers of anti-HHV6 IgG antibodies showed also a mild association with relapses, both in male and female patients (β = 0.01 [0.01–0.02]; p = 3.7 × 108 ). Both the genetic variation in MBP and HHV-6 infection aid in predicting a higher number of relapses during the first years of MS. The association described in MBP rs12959006T is exclusive to male patients
Result	Our study, and those from others, consolidates the contribution of rs12959006, within the MBP gene, as a marker to predict MS activity. Furthermore, according to our results, there seems to be an influence of both the genetic polymorphism in MBP and HHV-6 infection in predicting a higher relapse rate that is exclusive to male MS patients
Mechanism/Pathway	MBP is part of the peptide cocktail used for inducing experimental autoimmune encephalomyelitis (EAE) in mice, along with proteolipid protein (PLP) and myelin olygodendrocyte glycoprotein (MOG)