Basic information of CIITA :

Official Symbol of Gene	CIITA
Species	Homo sapiens
Entrez Gene ID	4261
Official Full Name	class II major histocompatibility complex transactivator
Also known as	C2TA; NLRA; MHC2TA; CIITAIV
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000179583 MIM:600005; AllianceGenome:HGNC:7067
Map Location	16p13.13
Variation Type	SNP
refSNP ID	rs3087456

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	PCR
Disease	MS
Disease subtype	N/A
Population	Swedish
Sample Size	466 unrelated Swedish MG patients and 1866 healthy control individuals

Literature information of multiple sclerosis :

Pubmed ID	20942939
Year	2010
Title	Lack of association of the CIITA -168AG promoter SNP with myasthenia gravis and its role in autoimmunity

Results of multiple sclerosis :

Risk Type	Disease risk
Main Result	We thus conclude that previous findings with regard to the role of the CIITA -168AG SNP in autoimmunity may have to be reconsidered
Result	No significant association of the SNP with MG was detected, neither in the patient group as a whole, nor in any clinical subgroup. The vast majority of previous replication studies have also not found an association of the SNP with autoimmune disorders
Mechanism/Pathway	The major histocompatibility complex class II transactivator (CIITA) regulates MHC class II gene expression